New wiki on saliva proteins could transform d

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image: A diagram that shows the interconnection of thousands of salivary proteins from blood plasma, parotid glands, and submandibular and sublingual glands. The diagram is one of many tools available to researchers and clinicians through the Human Salivary Proteome Wiki.
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Credit: National Institute for Dental and Craniofacial Research

BUFFALO, NY – To enhance the development of new diagnostic tests based on saliva and personalized medicine, the National Institute of Dental and Craniofacial Research (NIDCR) supported the development of the Human Salivary Proteome Wiki, the first public platform that lists and stores data on each of the thousands of proteins in our saliva.

Detailed in an article published on Tuesday, May 25 in the Dental research journal, the wiki provides researchers and clinicians with rich and unbiased evidence from several independent studies to help explore the dynamic and complex nature of saliva, as well as analytical tools to search for data by tissue type, disease and more. .

“This database and community knowledge will pave the way for harnessing the full potential of the salivary proteome for the diagnosis, risk prediction and treatment of oral and systemic diseases, and will increase preparedness for future diseases and pandemics. emerging, ”said Stefan Ruhl. , DDS, PhD, Study Principal Investigator, Curator of the Human Salivary Proteome Wiki, and Professor of Oral Biology at the University of the Buffalo School of Dental Medicine.

Saliva helps digestion, taste, swallow, and speech, and serves as the first line of defense against pathogens in the mouth, protecting the body from harmful microbes. The role of saliva in immune responses, as well as the ease with which it can be collected as a liquid sample, make it a desirable tool in precision medicine and non-invasive diagnostics. During the COVID-19 pandemic, it was widely used to detect the virus and track the body’s immune response.

A challenge in studying saliva, however, is the high level of variability in the thousands of salivary proteins. Therefore, normal ranges for the composition of saliva must be established to define the state of health, explains Ruhl, who in 2020 co-authored research on the manufacture of saliva, identifying the origins of the proteins of human saliva to its sources.

“Saliva has become an attractive bodily fluid for on-site, remote and real-time monitoring of oral and systemic health. The scientific community needs a saliva-centric information platform that keeps pace with the rapid accumulation of new data and knowledge, ”says William Lau, PhD, National Institutes of Health (NIH) and Premier author of the study.

“The Human Salivary Proteome Wiki will improve saliva science, saliva-based diagnostics, precision medicine and dentistry, and ultimately facilitate personalized treatment of oral and systemic diseases,” said Preethi Chander, PhD, director program of the NIDCR Salivary Biology and Immunology program. .

Modernized to “exploit the full potential of the salivary proteome”

Funded by NIDCR and developed in collaboration with the NIH Center for Information Technology, the Human Salivary Proteome Wiki was released in 2019 as a user-friendly public database to provide rich tools for analysis, curation, and annotation to the biomedical research community.

The database compiles information and research on the salivary proteome, genome, transcriptome (types and levels of mRNA expressed in salivary gland tissue), and glycoma (an array of sugars attached to salivary glycoproteins).

Users can submit proposals for adding, removing or modifying data to an interdisciplinary team of curators who ensure the information is accurate and supported by solid scientific evidence. Annotations are also assigned to researchers and clinicians who submit them to the wiki, helping to generate critical research references.

The researchers will also organize a series of activities that will bring together contributors to inspire new ideas and foster interdisciplinary collaborations.

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Other researchers and curators include Markus Hardt, PhD, senior manager of mass spectrometry at the Forsyth Institute; Yanhui Zhang, PhD, associate professor at the University of Tennessee Center for Health Sciences; and Marcelo Freire, DDS, PhD, associate professor at the J. Craig Venter Institute.


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