The health effects of cannabis and cannabinoids: current state of evidence and recommendations for research. Nih.gov. Accessed on 05/13/2021.
Corroon J, Felice JF. The endocannabinoid system and its modulation by cannabidiol (CBD). Altern Ther Health Med. 2019;25(S2):6-14.
Cannabidiol (CBD) – what we know and what we don’t know – Harvard Health Blog. Harvard Health Blog. Accessed on 05/13/2021.
Linares IM, Zuardi AW, Pereira LC, et al. Cannabidiol exhibits an inverted U-shaped dose-response curve in a simulated public speaking test. Revista brasileira de psiquiatria. 2019;41(1):9-14.
Zanelati TV, Biojone C, Moreira FA, Guimaraes FS, Joca SR. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol. 2010;159(1):122-128.
Commissioner’s Office. FDA approves first drug with active ingredient derived from marijuana to treat rare and severe forms of epilepsy. US Food and Drug Administration. Accessed on 05/13/2021.
L Elms, S Shannon, S Hughes, N Lewis. Cannabidiol in the treatment of post-traumatic stress disorder: a case series. The Journal of Alternative and Complementary Medicine. 2019;25(4):392-397.
Bitencourt RM, Takahashi RN. Cannabidiol as a therapeutic alternative for post-traumatic stress disorder: from laboratory research to confirmation in human trials. Frontiers in Neuroscience. 2018;12.
Hurd YL, Spriggs S, Alishayev J, et al. Cannabidiol for the reduction of cue-induced craving and anxiety in drug abstainers with heroin use disorder: a randomized, double-blind, placebo-controlled trial. American Journal of Psychiatry. 2019;176(11):911-922.
Hurd YL, Yoon M, Manini AF, et al. Early stage development of cannabidiol as a treatment for addiction: opioid relapse takes center stage. Neurotherapeutic. 2015;12(4):807-815.
Billsland LG, Dick JR, Pryce G, et al. Increasing Cannabinoid Levels Through Pharmacological and Genetic Manipulation Delays Disease Progression in SOD1 Mice. FASB J. 2006;20(7):1003-1005.
Meyer T, Funke A, Munch C, et al. Real experience of patients with amyotrophic lateral sclerosis (ALS) in the treatment of spasticity using tetrahydrocannabinol:cannabidiol (THC:CBD). BMC Neurol. 2019;19(1):222.
Russo EB. Cannabinoids in the management of hard-to-treat pain. Ther Clin Risk Management. 2008;4(1):245-259.
Xu DH, Cullen BD, Tang M, Fang Y. The efficacy of topical cannabidiol oil in the symptomatic relief of lower extremity peripheral neuropathy. Curr Pharm Biotechnol. 2020;21(5):390-402.
Weiss L, Zeira M, Reich S, et al. Cannabidiol reduces the incidence of diabetes in non-obese diabetic mice. Autoimmunity. 2006;39(2):143-151.
Rajesh M, Mukhopadhyay P, Batkai S, et al. Cannabidiol attenuates endothelial cell inflammatory response induced by high glucose and barrier disruption. American Journal of Physiology – Cardiac and Circulatory Physiology. 2007;293(1):H610-H619.
A randomized, double-blind, placebo-controlled, parallel-group, 1:1, 20:1 ratio pilot study of GWP42003 formulated: GWP42004 plus GWP42003 and GWP42004 alone for the treatment of dyslipidemia in subjects with type 1 diabetes. 2. clinicaltrials.gov. Accessed on 05/13/2021.
Mannucci C, Navarra M, Calapai F, et al. Neurological aspects of the medical use of cannabidiol. Drug targets for neurological CNS disorders. 2017;16(5):541-553.
Malfait AM, Gallily R, Sumariwalla PF, et al. Cannabidiol, a non-psychoactive constituent of cannabis, is an oral anti-arthritic treatment in murine collagen-induced arthritis. Proc Natl Acad Sci USA. 2000;97(17):9561-9566.
Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Cannabinoids as new anti-inflammatories. Future Med Chem. 2009;1(7):1333-1349.
Blake DR, Robson P, Ho M, Jubb RW, McCabe CS. Preliminary evaluation of the efficacy, tolerability and safety of a cannabis-based drug (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatology. 2006;45(1):50-52.
Hunter D, Oldfield G, Tich N, Messenheimer J, Sebree T. Synthetic transdermal cannabidiol for the treatment of knee pain due to osteoarthritis. Osteoarthritis and cartilage. 2018;26:S26.